Fig. 1
From: HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data
Overview of HATCHet2. Starting from aligned DNA sequence reads from one or more bulk tumor samples from the same patient, HATCHet2 identifies integer-valued copy-number profiles for multiple tumor clones along with the proportion of each clone in every sample. Steps in orange boxes indicate key methodological improvements in HATCHet2 compared to HATCHet [30], with orange text highlighting the new features in each step